Publications by authors named "V R Naidu"
In continuation of our efforts to develop new anticancer compounds, a new series of imidazo[1,5-]pyridine-chalcone derivatives was designed, synthesized, characterized, and evaluated for its cytotoxicity against five human cancer cell lines, , breast (MDA-MB-231), colon (RKO), bone (Mg-63), prostate (PC-3), and liver (HepG2) cell lines, as well as a normal cell line (HEK). Among the synthesized compounds, two exhibited promising cytotoxicity against the MDA-MB-231 cell line with IC values of 4.23 ± 0.
View Article and Find Full Text PDFThe persistence of viruses in human semen following acute infection can contribute to the ongoing transmission of a disease or cause resurgence after an outbreak has been declared ended. Viral persistence in semen affects embryonic development and male fertility, and the development of drugs and vaccines. We conducted a systematic review of viral persistence in semen in accordance with PRISMA guidelines.
View Article and Find Full Text PDFMesalamine is a locally acting anti-inflammatory drug used to treat mild to moderate ulcerative colitis. Because of complex formulation principle and high in vivo variability, development of bioequivalent formulation for mesalamine is challenging. Further, fed state possess significant challenges for bioequivalence (BE) due to interplay of multiple factors.
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- Alzheimer's disease (AD) is a progressive neurodegenerative condition that leads to significant cognitive decline and motor dysfunction due to the loss of cholinergic neurons, with current medications only providing temporary relief of symptoms.
- Novel compounds based on rivastigmine (such as 3q and 6e) were developed and shown to effectively inhibit key enzymes involved in AD, exhibit antioxidant properties, and prevent the aggregation of tau and Aβ proteins.
- These compounds also reduced inflammation in brain cells and restored memory function in animal models, showing increased expression of neuroprotection markers, indicating their potential for treating AD more effectively than existing medications.
Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a multifactorial, polygenic inflammatory disease. Mesua assamica (King & Prain) Kosterm. (MA) is an endangered medicinal plant indigenous to South Asia, primarily to Assam in India.
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