Publications by authors named "V R Gorodetskiy"
Article Synopsis
- T-cell leukemia from large granular lymphocytes (T-LGL leukemia) is a rare type of cancer, with γδT-LGL leukemia making up about 17% of cases and being linked to autoimmune diseases like rheumatoid arthritis (RA).
- A study analyzed 15 patients with γδT-LGL leukemia and rheumatologic diseases, finding that most had RA, with notable symptoms such as splenomegaly and neutropenia.
- The research highlighted that mutations were common, particularly in certain genes, and showed unusual characteristics of γδT-LGL leukemia, mainly affecting the spleen and not appearing in peripheral blood, prompting the need for further investigation into the relationship between this leukemia and RA.
Article Synopsis
- T-cell large granular lymphocyte (T-LGL) leukemia is characterized by increased large granular lymphocytes in the blood, neutropenia, and splenomegaly, but in rare 'aleukemic' cases, LGL levels are low, complicating diagnosis with related conditions like Felty syndrome in rheumatoid arthritis patients.
- The review discusses the characteristics and variants of aleukemic T-LGL leukemia, particularly the splenic variant, and highlights challenges in distinguishing it from hepatosplenic T-cell lymphoma.
- It emphasizes the importance of genetic testing for mutations in the STAT3 gene and thorough evaluation methods, including next-generation sequencing, for accurate diagnosis of this condition in RA patients.
Combination of Sjögren's syndrome and anti-Ku syndrome complicated by the development of mucosa-associated lymphoid tissue lymphoma: case review and systematic review of the literature.
Oksana Andreevna Golovina Anna Vasilievna Torgashina Vadim Romanovich Gorodetskiy Evgenia Vladimirovna Sockol Elena Georgievna Sagina
Clin Rheumatol
June 2024
The frequency of antibodies to Ku varies in various autoimmune diseases. In 2019, Spielmann et al. identified two types of anti-Ku syndrome based on a hierarchical clustering analysis.
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- - Neutropenia is common in Felty syndrome (FS) and T-cell large granular lymphocytic (T-LGL) leukemia associated with rheumatoid arthritis (RA), with TCR gene rearrangements supporting a diagnosis of T-LGL leukemia but not FS.
- - A study analyzed 100 RA patients with unexplained neutropenia, finding STAT3 mutations in 71% of those with RA-associated T-LGL leukemia versus only 10% in FS, indicating a significant difference (p=4.7×10-8).
- - The findings suggest that STAT3 mutations are rare in FS but common in T-LGL leukemia; detecting these mutations can help diagnose T-LGL leukemia even without TCR rearrangement
The relationship between Sjögren syndrome (SS) and T-cell large granular lymphocytic (T-LGL) leukemia remains unclear. In this paper, we report for the first time a large case series of 21 patients with primary and secondary SS associated with T-LGL leukemia. Our results suggest the importance of considering T-LGL leukemia in the diagnostic evaluation of SS patients, particularly when neutropenia occurs.
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