[Analysis of efficacy and safety of administration of moxonidine in patients with arterial hypertension and hypertensive crises].

In the review we present detailed analysis of antihypertensive action of 3-nd generation sympatholytic moxonidine. Due to selective interaction with imidazoline I1-receptors moxonidine diminishes sympathetic activity causing lowering of peripheral vascular resistance. This leads to significant lowering of systolic and diastolic arterial pressure.

[Sensitivity of the respiratory regulatory apparatus to CO2 under simulated space flight conditions].

Using the rebreathing method, CO2 sensitivity of the respiration regulation system was investigated during a year-long enclosure study and head-down tilt tests of varying duration (up to 120 days). During the exposures CO2 and H+ were built up in the body. In the course of the enclosure study CO2 sensitivity was reduced.

[Status of metabolism and peripheral circulation in man during antiorthostatic hypokinesia].

Metabolism and peripheral circulation were investigated in head-down tilt tests of varying duration. The greatest changes were seen on test day 30 when the subjects showed venous hyperoxia, lower oxygen arterio-venous difference and a significant (p less than 0.05) decrease of oxygen tension in arterial blood and oxygen utilization in tissues (p less than 0.