Publications by authors named "V Quan"
Background: Group B Streptococcus (GBS) is a leading cause of neonatal meningitis and sepsis and an important cause of disease in adults. Capsular polysaccharide and protein-based GBS vaccines are currently under development.
Methods: Through national laboratory-based surveillance, invasive GBS isolates were collected from patients of all ages between 2019 and 2020.
Article Synopsis
- Invasive pneumococcal disease (IPD) remains a serious global issue, particularly concerning non-vaccine serotypes, even after the introduction of pneumococcal conjugate vaccines (PCV) in South Africa.
- The study analyzed over 3,000 IPD genomes from children between 2005-2020, observing a drop in incidence for vaccine-type bacteria in the late-PCV13 period, but some continued to pose a threat.
- Notably, non-vaccine serotypes showed rising drug resistance and lineage diversity, indicating the need for ongoing genomic surveillance to inform health policies and future vaccine developments.
Background: In South Africa, 7-valent pneumococcal conjugate vaccine (PCV7) was introduced in 2009 and 13-valent PCV (PCV13) was introduced in 2011, both in a two plus one schedule. We evaluated the ongoing effects of PCV on the prevention of invasive pneumococcal disease (IPD) over 15 years of sustained surveillance in South Africa before the COVID-19 pandemic.
Methods: We conducted national, active, laboratory-based surveillance for IPD among all ages in South Africa, including isolate serotyping and susceptibility testing.
Tumors morphologically classified as pigmented epithelioid melanocytomas (PEMs) are genomically diverse, with the 2 most common genomic subtypes being PRKC fusions or PRKAR1A inactivating mutations. PRKC fusions activate the Gα q/11 pathway similar to blue nevi. Conversely, inactivating mutations in PRKAR1A activate the Gα s pathway.
View Article and Find Full Text PDF