Acute and chronic effects of perindopril on tissue angiotensin converting enzyme activity.

The pattern of inhibition of tissue angiotensin converting enzyme (ACE) was studied in rats after acute and chronic (14 days) oral administration of perindopril. Free and total tissue ACE were measured by quantitative in vitro autoradiography using [125I]-351A as a radioligand and compared with plasma ACE and pressor responses to angiotensin I. Following oral perindopril, plasma perindoprilic acid and the pattern of inhibition of plasma ACE activity were maximal at 1 to 2 h, but recovered over 24 h.

Inhibition of angiotensin-converting enzyme (ACE) in plasma and tissue.

Inhibition of angiotensin-converting enzyme (ACE) in rat plasma and tissue was studied after administration of quinapril, a new orally active ACE inhibitor with an intermediate duration of action. Tissue and plasma ACE was assessed by a radioinhibitor-binding assay and by in vitro autoradiography using [125I]351A as the radioligand. Individual tissues in rats were differentially inhibited in time and degree.

[Scanning electron microscopic study of penetrability of sealants in relation to fissure morphology of permanent premolars in humans].

In the work presented here, the morphological types of the fissure system in permanent human premolars are established, their average depth and width as well as the penetration capacity of fissure in relation to the morphological type of the fissure established (V, U, Y1, Y2). The largest average fissure depth was yielded by the Y2-configuration, the lowest by the V-type. The largest average entrance width was shown by the V-type, the lowest by the Y2-type.