Publications by authors named "V Prevot"
The use of incretin agonists for managing metabolic dysfunction-associated steatohepatitis (MASH) is currently experiencing considerable interest. However, whether these compounds have a direct action on MASH is still under debate. This study aims to investigate whether GLP-1R/GIPR agonists act directly in hepatocytes and hepatic stellate cells (HSCs).
View Article and Find Full Text PDFAstrocytes are now recognized as integral components of neural circuits, regulating their maturation, activity and plasticity. Neuroendocrinology has provided fertile ground for revealing the diverse strategies used by astrocytes to regulate the physiological and behavioural outcomes of neural circuit activity in response to internal and environmental inputs. However, the development of astrocytes in the hypothalamus has received much less attention than in other brain regions such as the cerebral cortex and spinal cord.
View Article and Find Full Text PDFLead (Pb) contamination in water requires improved decontamination technologies. The addition of phosphate to precipitate Pb is a widely used method for remediating Pb in soil and water, though it has certain limitations. This study focuses on novel 3D mesoporous layered double hydroxide (LDH) sorbents functionalized with phosphate anions for Pb removal from contaminated waters.
View Article and Find Full Text PDFArticle Synopsis
- The arcuate nucleus (ARH) in the hypothalamus is crucial for energy balance, as it detects metabolic hormones in the blood, but only a few neurons in this area can sense these signals due to a barrier involving the median eminence (ME).
- The study found that the proteoglycan aggrecan, produced by certain ARH neurons, establishes a diffusion gradient that limits the entry of these metabolic signals into the ARH, particularly during fasting when more aggrecan is deposited.
- Disrupting aggrecan deposits allows more blood-borne molecules to enter the ARH, leading to uncontrolled food intake, highlighting the importance of this diffusion barrier in the brain's metabolism regulation.
Article Synopsis
- GnRH neurons in the brains of adult male mice help them recognize females and are important for reproduction.
- These neurons can detect smells from females, like their urine, and send signals that trigger mating behaviors.
- If these GnRH neurons don’t work properly, male mice struggle to identify female scents and may have trouble mating.