"Joint protection first": understanding physiotherapists' implementation of evidence-based interventions in osteoarthritis knee management-a qualitative study.

Purpose: To explore the factors that influence physiotherapists' adherence to evidence-recommended interventions in the management of knee osteoarthritis.

Materials And Methods: Using a qualitative descriptive design, we conducted semi-structured interviews with 15 physiotherapists across India. Participants were selected using purposive sampling to ensure diversity in experience and setting.

Evaluation of biofilm formation and carbapenem resistance in isolated from clinical samples at a rural hospital in western Uttar Pradesh.

Introduction: commonly causes healthcare-associated infections and shows multidrug resistance. can produce biofilm. Carbapenem resistance in is due to the production of carbapenemases mainly.

Comparing standard treatment of moderate to severe obstructive sleep apnoea to add-on acetazolamide treatment: An open-label randomised controlled trial.

Background And Objective: Obstructive sleep apnea (OSA) is a common condition, featured by repetitive upper airway collapse during sleep manifested with poor quality of life and co-morbidities. Although continuous positive airway pressure (CPAP) is the recommended therapy, lack of patient compliance and persistent symptoms often preclude its success. The present study evaluates the effect of acetazolamide in combination with CPAP, and compares this treatment strategy to single therapy using CPAP in moderate to severe OSA.

Mechanistic and structural insights into EstS1 esterase: A potent broad-spectrum phthalate diester degrading enzyme.

Phthalate diesters are important pollutants and act as endocrine disruptors. While certain bacterial esterases have been identified for phthalate diesters degradation to monoesters, their structural and mechanistic characteristics remain largely unexplored. Here, we highlight the potential of the thermostable and pH-tolerant EstS1 esterase from Sulfobacillus acidophilus DSM10332 to degrade high molecular weight bis(2-ethylhexyl) phthalate (DEHP) by combining biophysical and biochemical approaches along with high-resolution EstS1 crystal structures of the apo form and with bound substrates, products, and their analogs to elucidate its mechanism.