Biomarkers.

Background: Vocal biomarkers are emerging as potentially meaningful health indicators in multiple domains, including cognition. Because voice-enabled devices are widespread, automated vocal analysis could become a useful modality for early detection and monitoring of cognitive impairment. To assess the efficacy of vocal biomarkers in identifying cognitive impairment we evaluated prosodic speech features on vocal tasks in a research cohort from Kerala, India, and a referral cohort from the Montefiore-Einstein Center for the Aging Brain in the Bronx, NY.

Biomarkers.

Background: The Motoric Cognitive Risk Syndrome (MCR) is a predementia stage characterized by slow gait speed and subjective cognitive complaints. Defining the heterogeneity of brain volumetrics in individuals with MCR will improve current dementia risk assessments.

Method: We used data from 6 cohorts from the MCR consortium (N=2,007).

Alzheimer's Imaging Consortium.

Background: The Motoric Cognitive Risk Syndrome (MCR) is a predementia stage characterized by slow gait speed and subjective cognitive complaints. Defining the heterogeneity of brain volumetrics in individuals with MCR will improve current dementia risk assessments.

Method: We used data from 6 cohorts from the MCR consortium (N=2,007).

Hyperparameter tuning using Lévy flight and interactive crossover-based reptile search algorithm for eye movement event classification.

Eye movement is one of the cues used in human-machine interface technologies for predicting the intention of users. The developing application in eye movement event detection is the creation of assistive technologies for paralyzed patients. However, developing an effective classifier is one of the main issues in eye movement event detection.

Mechanically controlled multifaceted dynamic transformations in twisted organic crystal waveguides.

This study introduces mechanically induced phenomena such as standing, leaning, stacking, and interlocking behaviors in naturally twisted optical waveguiding microcrystals on a substrate. The microscale twisted crystal self-assembled from 2,4-dibromo-6-(((2-bromo-5-fluorophenyl)imino)methyl)phenol is flexible and emits orange fluorescence. Mechanistic analysis reveals the strain generated by the intergrowing orientationally mismatched nanocrystallites is responsible for the twisted crystal growth.