The frequency of clinical pregnancy and implantation rate after cultivation of embryos in a medium with granulocyte macrophage colony-stimulating factor (GM-CSF) in patients with preceding failed attempts of ART.

The application in IVF practice of modern techniques can improve positive outcome of each cycle in the assisted reproductive technology (ART) programs and the effectiveness of treatment as a whole. There are embryos in the female reproductive tract in physiological medium which contain various cytokines and growth factors. It plays an important role in the regulation of normal embryonic development, improve implantation and subsequently optimizing the development of the fetus and the placenta.

[Effects of individual and combined administration of ethylmethylhydroxypyridine succinate and ischemic preconditioning on ischemic-reperfusive myocardial injury in rats].

It was shown previously that ethylmethylhydroxypyridine succinate (EMHPS) can produce metabolic cardioprotective action due to its antihypoxant and antioxidant properties. In the present study, the cardioprotective effects of EMHPS administered in doses 50 and 100 mg/kg alone and in combination with ischemic preconditioning have been studied on the model of ischemic-reperfusive myocardial infarction in rats. It is established that both the administration of EMHPS in a dose 50 mg/kg and the ischemic preconditioning produce significant limitation of the infarction size.

[The effects of modulation of cardiac metabolism and antioxidant state on myocardial ischemia-reperfusion injury].

The effects of mexicor (ethylmethylhydroxypyridine succinate) at doses of 50 and 100 mg/kg on myocardial infarct size, serum levels of myocardial markers, and severity of ischemia- and reperfusion-induced arrhythmias were studied in the rat model of myocardial ischemia-reperfusion injury. It was shown that pre-ischemic intravenous infusion of mexicor at a dose of 50 mg/kg resulted in significant reduction of myocardial infarct size and troponin I level. When the dose of mexicor was increased up to 100 mg/kg the infarct-limiting effect was reversed.

[Effect of mexicor on oxidative stress in acute myocardial infarction].

Mexicor (5% solution and capsules) was used in 40 of 80 conventionally treated patients with acute myocardial infarction. The drug was given intravenously for 5 days, than intramuscularly (6-9 mg/kg) for 9 days and orally (0.1 mg t.

[Urapidil effects on oxidative stress in hypertensive crises].

Urapidil effects on oxidant stress were studied in 36 patients with hypertension stage I-III running with crises. Acute hypertensive crisis was managed by intravenous injections of urapidil (20-50 mg) for 5 min. After that for a week they received urapidil monotherapy followed by combined treatment for another week (quinapril--25 mg/day or ramipril--5-10 mg/day in combination with hypothiaside--25 mg/day; lokren--20 mg/day or atenolol--50-100 mg/day and diltiazem--180-360 mg/day) to stabilize arterial pressure finally.