[Possibilities in the use of cell cultures in carcinogenicity tests].

The cell transformational test, consisting in morphological transformation of the human embryonal lung cells, is a rapid and sensitive method of identification of chemical carcinogens. The test is capable of revealing carcinogens undetectable by other methods and it makes it possible to avoid mistakes due to inter-species differences in the biotransformation of the drugs tested.

Biological effects of some N-substituted (meth)acrylamides.

This paper reports an investigation of the biological effects of monomers of N-substituted (meth)-acrylamides used in the preparation of polymers suitable for medical purposes. By combining tests carried out on cell cultures and on living animals, we found thpheral nervous system. Tests performed on cell cultures can be used as preliminary and supplementary ones in testing the toxicity of substances on living animals.

CV-1 monkey kidney cell line -- a highly susceptible substrate for diagnosis and study of arboviruses.

The CV-1 cell line, derived from Cercopithecus aethiops monkey kidneys, acquired in the course of serial passaging an epitheloid morphology and heteroploid karyotype. As compared with Vero and GMK cell lines, the CV-1 line proved to be more susceptible to a broad spectrum of arboviruses belonging to the families Togaviridae and Bunyaviridae. Most of them reached high titres and were markedly cytopathic in CV-1 cells so that all tests based on the cytopathic effect could be carried out.

Biological tolerance of copolymers of 2-hydroxyethyl methacrylate-vinylpyridine.

The healing-in of implants of terpolymer gels having different chemical composition was studied in animals. Histological analysis showed that all polymers under investigation are healed-in in a similar way by encapsulation with collagen fibrous tissue. Neither cancerogenic effect nor calcification were observed within the interval studied.