Publications by authors named "V Pichler"
Background: Poly (ADP-ribose) polymerase (PARP) enzymes are crucial for the repair of DNA single-strand breaks and have become key therapeutic targets in homologous recombination-deficient cancers, including prostate cancer. To enable non-invasive monitoring of PARP-1 expression, several PARP-1-targeting positron emission tomography (PET) tracers have been developed. Here, we aimed to preclinically investigate [carbonyl-C]DPQ as an alternative PARP-1 PET tracer as it features a strongly distinct chemotype compared to the frontrunners [F]FluorThanatrace and [F]PARPi.
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- The study focuses on five species of Phortica flies in Europe and the Middle East, particularly Phortica variegata and Phortica okadai, known as vectors for the zoonotic eyeworm Thelazia callipaeda, in a region near Rome, Italy.
- Over three years (2018-2020), researchers collected and identified nearly 5,600 flies, revealing a dominance of Phortica variegata, which was found to be infected with T. callipaeda, while Phortica oldenbergi showed differing behavior in fruit traps.
- Environmental factors like temperature, wind speed, and pressure influenced the population dynamics of these species, with the study being the first to explore these ecological interactions
Micro- and nanoplastics can interact with various biologically active compounds forming aggregates of which the effects have yet to be understood. To this end, it is vital to characterize these aggregates of key compounds and micro- and nanoplastics. In this study, we examined the adsorption of the antibiotic tetracycline on four different nanoplastics, made of polyethylene (PE), polypropylene (PP), polystyrene (PS), and nylon 6,6 (N66) through chemical computation.
View Article and Find Full Text PDFThe two main Afrotropical malaria vectors - Anopheles coluzzii and An. gambiae - are genetically distinct and reproductively isolated across West Africa. However, populations at the western extreme of their range are assigned as "intermediate" between the two species by whole genome sequence (WGS) data, and as hybrid forms by conventional molecular diagnostics.
View Article and Find Full Text PDFMulberry Diels-Alder-type adducts (MDAAs), isolated from root bark, exhibit dual activity against viral and bacterial pathogens but show sobering efficacy following oral administration. Inhalation administration may overcome issues with oral bioavailability and improve efficacy for the treatment of respiratory infections. To assess the suitability of MDAAs for inhalation administration, physicochemical (e.
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