The role of autophagy in the regulation of neuroinflammation in acute ischemic stroke (review of literature).

Postischemic neuroinflammation is a critical pathophysiological process within the entire scheme of cerebral ischemia, covering early damage and the period of tissue repair. It is characterized by microglial and astroglial activation with increased expression of inflammatory mediators and is accompanied by impaired innate and adaptive immune responses. In acute ischemic stroke (IS), neuroinflammation is caused by the response of resident immune cells of microglia and peripheral immunocompetent cells infiltrating the brain tissue, which penetrate the blood-brain barrier (BBB) into the lesion.

[Preconditioning by physical factors: role of active forms of oxygen].

In the review mechanisms of protective action of a hyperthermia, light and low-intensity ultrasonic radiation are considered. These physical factors don't cause oxygen starvation, however promote the increase of organ's tolerance to an ischemia/hypoxia. On materials of original articles the analysis of preconditioning mechanisms cause by high temperatures, low-intensive ultrasonic and laser irradiation was carried out at ischemia.

[The effect of morphine and pentazocine on thrombocyte functional activity].

The effect of morphine (0.02 and 0.05 mg/ml) and pentazocine (0.

[Microvascular hemostasis in the phase of postradiation recovery].

Laser-induced thrombosis was used for studying of thrombogenic properties and thromboresistance of microvessels after total gamma irradiation with a dose of 2 Gy. The increased time of primary haemostasis was stated during postirradiation period. The area of thrombus section was reduced both in the arterioles and the venules after 1 month.

[Aggregational thrombocyte activity in rats in post-radiation rehabilitation].

Platelet aggregation in rats was investigated after total gamma-irradiation with a dose of 2 Gr. At period postirradiation repair the phase character of changes of some aggregation parametres was discovered. After 2-6 months the main direction of age changes of aggregation activity was preserved, but disaggregation time was lesser then in control group.