A new class of antiulcer drugs. I. Antiulcer effect of AN5, a 4-phenyl-tetrahydroisoquinoline derivative, on different experimental models of ulcer in rats.

The action of AN5 on experimental models of gastric ulcers induced by water-immersion stress, indomethacin and reserpine, or by pylorus ligation in rats has been studied. AN5 supresses the formation of ulcers in all experimental models. The strongest antiulcer effect is shown in relation to water-immersion stress-induced ulcers.

Biopharmaceutical studies of oral formulations containing propyphenazone.

Studies were performed with oral dosage formulations of propyphenazon, i.e. aqueous suspension (1%), instant suspension (1%) and tablets (100 mg) for pediatric use.