Publications by authors named "V Pascual"
Article Synopsis
- * Daily PM₂.₅ (a harmful air pollutant) levels were significantly higher on wildfire days (34 µg/m) compared to non-wildfire days (25.75 µg/m), indicating a link to fire events.
- * The risk of ST-elevation myocardial infarction (STEMI) increased with higher PM₂.₅ levels, especially when concentrations exceeded 20 µg/m, suggesting that wildfires contribute to heart health risks.
Article Synopsis
- Opsonization of mitochondria-containing red blood cells (Mito RBCs), common in systemic lupus erythematosus (SLE), activates macrophages to produce type I interferon (IFN) and interleukin-1β (mIL-1β) in response to these cells.
- This IFN production is influenced by the detection of mitochondrial DNA (mtDNA) and mitochondrial RNA (mtRNA) from Mito RBCs, utilizing pathways involving cyclic GMP-AMP synthase (cGAS) and RIG-I-like receptors (RLRs).
- The release of mIL-1β, crucial for inflammatory responses, operates through a different pathway