Publications by authors named "V Parietti"
Article Synopsis
- Hematopoietic multipotent progenitors (MPPs) in the bone marrow can differentiate into various cell types, influenced by both intrinsic and extrinsic signals, with WHIM syndrome patients exhibiting an excess of myeloid cells due to CXCR4 signaling mutations.
- Research using knock-in mice with WHIM-associated mutations showed that MPP4 cells, which usually develop into lymphoid cells, instead skewed towards myeloid differentiation due to increased mTOR signaling and altered oxidative phosphorylation.
- Treatment with CXCR4 antagonist AMD3100 or mTOR inhibitor rapamycin reversed this myeloid bias, indicating that normal CXCR4 function is crucial for maintaining the lymphoid potential of MPP4 cells by regulating
Myeloproliferative neoplasms (MPNs) are characterized by an increased production of blood cells due to the acquisition of mutations such as JAK2. TGF-β, whose secretion is increased in MPN patients, is known to negatively regulate haematopoietic stem cell (HSC) proliferation. Using an isogenic JAK2 or JAK2 wild-type UT-7 cell line we observed that JAK2 cells resist to TGF-β antiproliferative activity.
View Article and Find Full Text PDFBone metastases are the most common milestone in the lethal progression of prostate cancer and prominent in a substantial portion of renal malignancies. Interactions between cancer and bone host cells have emerged as drivers of both disease progression and therapeutic resistance. To best understand these central host-epithelial cell interactions, biologically relevant preclinical models are required.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the use of mucosal-associated invariant T (MAIT) cells to prevent or reduce graft-versus-host disease (GVHD), a significant complication after stem cell transplants.
- Researchers found that MAIT cells can inhibit the activation of alloreactive T cells in vitro and effectively delay or lessen the severity of GVHD in a preclinical mouse model when given shortly after PBMC infusion.
- The immunosuppressive effects of MAIT cells were linked to reduced levels of inflammatory cytokines like IFN-γ and TNF-α, while increasing anti-inflammatory IL-10, suggesting MAIT cells could be a promising treatment for GVHD and related conditions in future