In silico investigation of cholesterol-lowering drugs to find potential inhibitors of dehydrosqualene synthase in .

Unlabelled: is a lethal pathogen that can cause various bacterial infections. This study targets the CrtM enzyme of , which is crucial for synthesizing golden carotenoid pigment: staphyloxanthin, which provides anti-oxidant activity to this bacterium for combating antimicrobial resistance inside the host cell. The present investigation quests for human SQS inhibitors against the CrtM enzyme by employing structure-based drug design approaches including induced fit docking (IFD), molecular dynamic (MD) simulations, and binding free energy calculations Depending upon the docking scores, two compounds, lapaquistat acetate and squalestatin analog 20, were identified as the lead molecules exhibit higher affinity toward the CrtM enzyme.

PlantAFP: a curated database of plant-origin antifungal peptides.

Emerging infectious diseases (EIDs) are a severe problem caused by fungi in human and plant species across the world. They pose a worldwide threat to food security as well as human health. Fungal infections are increasing now day by day worldwide, and the current antimycotic drugs are not effective due to the emergence of resistant strains.

Effects of prenatal exposure to benzodiazepine-related drugs on early development and adult social behaviour in Swiss mice--II. Antagonists.

1. The present experiment examined, using a battery of tests, the effects of in utero exposure of Swiss mice to the benzodiazepine antagonists Ro 15-1788 and CGS 8216 upon early development and adult behaviour. 2.

Effects of prenatal exposure to benzodiazepine-related drugs on early development and adult social behaviour in Swiss mice--III. Inverse agonists.

1. The present experiment examined, using a battery of tests, the effects of in utero exposure to the benzodiazepine inverse agonists DMCM and FG 7142 upon the early development and adult behaviour of Swiss Mice. 2.

Effects of prenatal exposure to benzodiazepine-related drugs on early development and adult social behaviour in Swiss mice--I. Agonists.

1. The present experiment examined, using a battery of tests, the effects of in utero exposure to the benzodiazepine agonists chlordiazepoxide and midazolam upon the early development and adult behaviour of offspring of Swiss mice. 2.