Treatment results and predictors of local recurrences after breast conserving therapy in early breast carcinoma.

Purpose: The aim of this study was to access the influence of several factors on local control (LC) and overall survival (OS) in patients with early breast cancer after breast-conserving therapy.

Patients And Methods: 122 early breast cancer patients with tumor (T) up to 3 cm and breast-conserving surgery followed by radiotherapy, chemotherapy, or hormonal therapy were retrospectively analysed. Factors considered to carry possible significance in relation with local recurrence were classified into 3 groups that included characteristics of the patient, of the tumor and the non-surgical treatment methods applied.

Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin in male and female turkeys following intravenous and oral administration.

The pharmacokinetics of enrofloxacin (EFL) was investigated in turkeys (6 male and 6 female; 7-month-old at the start of the experiment), after intravenous and oral administration at a dose of 10 mg/kg body weight. The serum concentrations of EFL and its active metabolite ciprofloxacin (CFL) were determined by high-performance liquid chromatography. The serum concentrations vs time were analysed by a compartmental analysis.

[Conservative therapy of I and II stage breast cancer--successful alternative to modified radical mastectomy].

A clinical trial was conducted at the Center's Clinic to compare breast conserving treatment (quandrantectomy + radiation) (BCT) with modified radical mastectomy (M). It included 190 patients with stage I-II carcinoma up to 30 mm (BCT with "negative margin"--122; M--68). All the patients had undergone full axillary dissection.

[The course of skin radiation reactions after treatment with the preparation nucliderm-gel].

The process of epithelialization and the antiseptic effect of nucliderm-gel applied locally have been studied on 63 oncologic patients subjected to radiotherapy. In all cases under study, nucliderm-gel promotes skin epithelialization and has a high antiseptic effect as compared with the drugs applied hitherto.