[Endotoxin tolerance of mice to the effect of lipopolysaccharide and lipopolysaccharide-mice toxin complex of virulent strain Yersinia pestis 231].

Aim: Comparative study of the effect of endotoxin tolerance of mice to the effect of lipopolysaccharide (LPS37) and complex of lipopolysaccharide with mice toxin (LPS37-MT) of a virulent Yersinia pestis 231 strain.

Materials And Methods: Preparations of LPS of highly virulent strain Y. pestis 231 obtained by phenol method from cells cultivated at 37 degrees C as well as commercial preparations of S-LPS and R-LPS of Escherichia coli were used.

[Toxicity and cytokine-inducing activity of lipopolysaccharide of virulent Yersinia pestis 231 strain].

Aim: Determine correlation between toxicity and cytokine inducing activity of parent and conformation modified forms of lipopolysaccharides (LPS) of virulent Yersinia pestis strain.

Materials And Methods: LPS was isolated by phenol method from Y. pestis 231 cells grown at 37 degrees C (LPS37).

[Toxicity of Yersinia pestis EV76 lipopolysaccharides for mice sensitized by D-galactosamine].

Aim: To study toxicity of lipopolysaccharides (LPS28 and LPS 37) of Yersinia pestis for mice sensitized by D-galactosamine (D-GalN).

Materials And Methods: LPS were obtained by the Westphal method from Y. pestis EV76 strain grown at temperatures of 28 and 37 degrees C.

[Effect of Yersinia pestis EV 76 lypopolysaccharides with different levels of toxicity on dynamics of TNF-alpha and INF-gamma synthesis by human monocytes].

Unlabelled: AIM. To study dynamics of synthesis of TNF-alpha and INF-gamma by cell line U-937 human monocytes under the effect of Yersinia pestis EV 76 lypopolysaccharides (LPS) with different levels of toxicity: original LPS28 and LPS37 as well as their conformationally--changed variants with enhanced toxicity--complex of LPS with murine toxin (MT) of Y. pestis, and LPS modified by biologicall active compound (BAC) obtained from human erythrocytes.

[The activation of Yersinia pestis "murine" toxin and endotoxin by hemolyzed erythrocytes from mammalian blood].

Y. pestis "mouse" toxin and endotoxin have been found to be capable of being activated with hemolyzed mammalian red blood cells. The LD50 of the activated endotoxin decreases 5-10 times in comparison with the initial preparation.