Publications by authors named "V P Wallace"
Article Synopsis
- Cancer-specific T cells often fail to eliminate tumors, so researchers explored using CD4 T cell receptors (CD4TCRs) from tumor-bearers for new treatments.
- They focused on TCRs that target unique neoantigens presented by the surrounding tissue of MHC class II-negative cancer cells, testing the 11 most common TCRs.
- Some TCRs shared similar structures despite different sequences, effectively attacking tumors and reversing tumor progression; choosing TCRs based on their genetic similarities may enhance therapeutic success.
Central nervous system (CNS) injuries and neurodegenerative diseases have markedly poor prognoses and can result in permanent dysfunction due to the general inability of CNS neurons to regenerate. Differentiation of transplanted stem cells has emerged as a therapeutic avenue to regenerate tissue architecture in damaged areas. Electrical stimulation is a promising approach for directing the differentiation outcomes and pattern of outgrowth of transplanted stem cells, however traditional inorganic bio-electrodes can induce adverse effects such as inflammation.
View Article and Find Full Text PDFHealth promotion programs and strategies have the potential to support people to live healthier lives. Dementia, a collective name for brain disorders that impact thinking and memory, affects over 55 million people worldwide. Currently, there is no cure for dementia, so prevention is critical.
View Article and Find Full Text PDFA roadmap for medical device innovators is presented that highlights the essential steps for regulatory authorization, market access, and reimbursement strategies in the USA, with a focus on strategic planning for commercial success, underscoring the integration of regulatory and market access considerations from the initial development of a medical device.
View Article and Find Full Text PDFArticle Synopsis
- - Limited understanding exists regarding the broader impacts of antidepressant withdrawal, beyond just physical side effects, highlighting the need for more research on users' experiences during this process.
- - The study involved qualitative interviews with 20 individuals who had attempted to stop using Serotonin Reuptake Inhibitor antidepressants, revealing five key themes about their withdrawal experiences.
- - Participants noted that withdrawal affects emotional, cognitive, and social well-being, stressing the importance of flexible tapering strategies and the role of support systems, such as family and healthcare providers.