Publications by authors named "V P Vodoevich"

The article criticizes a standard approach to essential hypertension treatment based for the most part on b-adrenoblokers, calcium channel blockers and angiotensin-converting enzyme inhibitors. The author proposed an individual approach to managing hypertension based on Lang neurogenic theory with taking into consideration different types of hypertensive attacks.

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In 60 patients with stable functional class II exertional angina with hyperkinetic type of circulation, baseline hemodynamics was studied following a 2-week treatment. A negatively chrono- and inotrophic effect was observed with taking anaprilin in a dose of 160 mg per day and a dose of 80 mg per day combined with 2 ml of 5 per cent solution of thiamine-chloride in injections. No effect was elicited with an 80 mg/d anaprilin without thiamine.

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The data of clinic observation and ECG-monitoring show that ascorbic acid significantly increases antianginal vasodilatory effects of nitroglycerine thus preventing from development of ischemic miocardial reaction in response to complamin injection. Incubation under anaerobe conditions of ascorbic acid solution with NO-donors (sodium nitrate, nitroglycerine) or with the blood of ischemic patients who had been treated for a long time with long-acting nitrovasodilators, results in liberation in Varburg vasculium of gas bubbles identified as nitrogen oxide according to hemoglobin nitrosylation. Activation of endogen NO-donors with ascorbic acid and taking antilogs of antianginal effects of exogenous nitroglycerine makes it possible to substantially increase the efficiency of nitratotherapy and nitratoprophylaxis of angina pectoris.

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Glycosylated amino acids and glycosylated human serum albumin reduce nitrite to nitric oxide under anaerobic conditions. The amount of nitric oxide produced was recorded by generation of nitrosoHb from deoxyHb. Without preincubation after the addition of sodium nitrite, glucose or a mixture of glucose with amino acid or serum albumin did not cause spectrophotometrically detectible transformation of deoxyHb into nitrosoHb.

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The fraction of Amadori products gradually decreased during heavy glycosylation of amino acids and human serum albumin while the amount of a colored product with the maximum fluorescence at 420 nm decreased. The addition of the produced ketoamines of amino acids to the solution of native albumin quenched its own fluorescence due to generation of a Schiff base with amino groups of the protein. Carbonyl-containing Amadori products obtained during the early steps of glycosylation were less potent electron donors than amino acids more heavily modified by the carbohydrate.

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