Publications by authors named "V P Verghese"
Sequential and parallel testing for microbiological confirmation of tuberculosis disease in children in five low-income and middle-income countries: a secondary analysis of the RaPaed-TB study.
Lancet Infect Dis
September 2024
Article Synopsis
- Researchers looked into how to test kids under 15 for tuberculosis, a serious illness that can be missed in many children.
- They studied data from five countries and included children who showed signs of the disease, while excluding very sick kids or those already on treatment.
- Out of 975 kids tested, 25% were confirmed to have tuberculosis, 29% were thought to have it but not confirmed, and 46% were unlikely to have it.
Approach to fever in children.
Indian J Med Microbiol
August 2024
Background: Fever in children is one of the most common reasons for outpatient visits as well as in-patient evaluation, often causing anxiety among parents and caregivers. Fever can be a standalone feature or be associated with other localising symptoms and signs like rash, lymphadenopathy, or any other organ system involvement with or without a focus of infection. The etiologies of fever vary depending on the clinical setting and epidemiology.
View Article and Find Full Text PDFThe nature of vaccine response inferiority is not well studied in children living with HIV (CLHIV). The authors investigated Hepatitis B Virus (HBV) and Diphtheria/Pertussis/Tetanus toxoid (DPT) vaccination responses following primary immunization in CLHIV (n = 42) and healthy controls (HC) (n = 38) and the effect of an additional vaccine dose. Antibody responses, CD4 and HBV-specific T/B cells were analysed using CMIA/ELISA and flow-cytometry.
View Article and Find Full Text PDFArticle Synopsis
- Emerging infectious diseases, particularly zoonotic ones, necessitate a "One-Health" surveillance approach, highlighting the need for standardized diagnostic protocols to manage clinical differentiation and combat antimicrobial resistance.
- The Indian Council of Medical Research (ICMR) has developed a comprehensive diagnostic and surveillance algorithm for acute respiratory infections (ARIs) to improve early detection and treatment, aiming to create a blueprint for managing respiratory infection outbreaks in India.
- This structured approach to diagnosing respiratory illnesses prioritizes pathogens based on prevalence, severity, and public health impact, utilizing a mix of traditional, innovative, and radiological methods to ensure effective identification and monitoring of infections.