Publications by authors named "V P Tripodi"
Background: The impact of noninvasive ventilation (NIV) managed outside the intensive care unit in patients with early acute respiratory failure remains unclear. We aimed to determine whether adding early NIV prevents the progression to severe respiratory failure.
Methods: In this multinational, randomised, open-label controlled trial, adults with mild acute respiratory failure (arterial oxygen partial pressure/fraction of inspiratory oxygen [Pao/FiO] ratio ≥200) were enrolled across 11 hospitals in Italy, Greece, and Kazakhstan.
Clostridioides difficile is a spore-forming pathogen capable of causing severe disease in humans. Critical stages in the biological cycle of this microorganism include sporogenesis/germination and toxin production by vegetative cells. Antagonizing these pivotal events could aid in prevention and treatment to manage this pathogen.
View Article and Find Full Text PDFSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has put enormous pressure on healthcare systems worldwide. While the majority of severe cases present with respiratory failure, thrombosis or bleeding have also been reported at unusual sites. Major bleeding, particularly in patients treated with therapeutic anticoagulation, has been observed between the second and third week after the onset of SARS-CoV-2 infection.
View Article and Find Full Text PDFArticle Synopsis
- - ERCP (endoscopic retrograde cholangiopancreatography) is a crucial procedure for diagnosing and treating biliopancreatic disorders, utilizing a mix of endoscopy and radiology to address issues like bile duct stones and leaks.
- - The procedure often requires anesthesia due to its discomfort, with options ranging from moderate sedation to general anesthesia, making the choice of anesthetic methods significant.
- - A narrative review was conducted to evaluate current anesthetic medications used during elective ERCP, particularly focusing on new drugs like dexmedetomidine, amidst ongoing debates about sedation levels and airway management practices.
Background: Reintubation is associated with higher risk of mortality. There is no clear evidence on the best spontaneous breathing trial (SBT) method to reduce the risk of reintubation.
Research Question: Are different methods of conducting SBTs in critically ill patients associated with different risk of reintubation compared with T-tube?
Study Design And Methods: We conducted a systematic review and Bayesian network meta-analysis of randomized controlled trials investigating the effects of different SBT methods on reintubation.