Publications by authors named "V P Torchilin"
Article Synopsis
- Disulfiram, a medication previously used for alcohol addiction, is being studied as a cancer treatment due to its ability to inhibit cancer cell growth and enhance the effectiveness of chemotherapy and radiation.
- The drug induces apoptosis (cell death) in cancer cells and can be effective against various types of cancer, including breast and prostate cancer.
- Researchers are focusing on new delivery systems, like polycaprolactone-based nanocapsules, which improve the drug's stability and cytotoxicity, suggesting a promising avenue for more effective and safer cancer treatments.
Article Synopsis
- Effective targeting using nano drug delivery systems (NDDS) helps deliver medications directly into cancer cells, improving treatment efficiency by overcoming cellular defenses.
- The study developed a dual-responsive nanoparticle system loaded with the chemotherapy drug DTX that activates specifically in the tumor environment, leading to a significant release of the drug.
- In tests, the new formulation showed 5 times greater cytotoxicity compared to free DTX, effectively inhibiting tumor growth in mice with lower doses, indicating a promising advancement in cancer treatment strategies.
Advances in siRNA Drug Delivery Strategies for Targeted TNBC Therapy.
Bioengineering (Basel)
August 2024
Among breast cancers, triple-negative breast cancer (TNBC) has been recognized as the most aggressive type with a poor prognosis and low survival rate. Targeted therapy for TNBC is challenging because it lacks estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Chemotherapy, radiation therapy, and surgery are the common therapies for TNBC.
View Article and Find Full Text PDFBreast cancer is potentially a lethal disease and a leading cause of death in women. Chemotherapy and radiotherapy are the most frequently used treatment options. Drug resistance in advanced breast cancer limits the therapeutic output of treatment.
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