[The function of enzymes for the antioxidative protection of the bone marrow cells in rats during irradiation, bone fracture and combined radiation injury].

The activity of superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione: dehydroascorbate oxidoreductase is lower in the bone marrow than in the liver. The changes in the cellular antioxidative enzymatic system during leg bones fracture and X-ray irradiation are more pronounced in the rat bone marrow, as compared to the liver. The data obtained are in keeping with selective bone-marrow radiosensitivity and with the effect of exogenous superoxide dismutase and glutathione as radioprotectors.

[Effect of a combined radiation lesion on the enzyme activity of the glutathione redox system of the rat liver].

A study was made of activity of glutathione peroxidase, glutathione reductase and glutathione-dehydroascorbate oxidoreductase in the rat liver under x-ray treatment in doses of 206 or 155 mC/kg coupled with mechanical injury (closed fracture of the leg bones). Radiation in a dose of 206 mC/kg gave rise to the following changes in activity of glutathione redox-system enzymes: reduced activity of glutathione peroxidase on the 3d day, and increased activity of glutathione reductase, and glutathione-dehydroascorbate oxidoreductase on the 7th day after combined radiation injury. Radiation in a dose of 155 mC/kg was accompanied by increased activity of glutathione-dehydroascorbate oxidoreductase on the 7th day and reduced glutathione reductase activity on the 30th day after the injury infliction.

[Incorporation of labeled cortisol into different types of connective tissue].

The properties of early (BFUen) and late (CFUen) erythropoietin-independent progenitors were studied in bone marrow plasma clot cultures of mice. Syngeneic serum was used as a stimulant of colony formation. It was revealed that serum from polycytemic mice did not alter the efficacy of cloning the erythroid progenitors.