Acute stress was simulated in Wistar rats by means of uncontrolled electric shock within 6 hrs; chronic stress, after the first 6-hr course, was developed within 9 days using 1-h daily treatment. Within 18 hrs of the acute stress occurring concentration of serotonin was decreased 2-fold in tissues of brain cortex, while reverse absorption of the neurotransmitter in synaptosomes was increased 3-fold. Under conditions of chronic stress concentration of serotonin tend to increase, whereas reverse absorption by nerve endings was decreased, which appear to occur due to brain adaptation to chronic stress.
View Article and Find Full Text PDFThe systems regulating the levels of Ca(2+)-Mg2+, Ca(2+)-ATPase and potential-dependent absorption of Ca2+ as well as content of cyclic nucleotides, beta-adrenoreceptors, activities of adenylate-, guanylate cyclases and phosphodiesterase were studied in the synaptosomes of rat brain cortex in evolving myocardial infarction. In addition, reverse absorption of noradrenaline, dopamine and serotonin was studied. In one of the animal groups myocardial infarction was simulated after stress.
View Article and Find Full Text PDFSynaptosomes and synaptic membranes were studied in brain cortex of rats after 6 hrs emotional-painful stress. No alterations were observed in beta-adrenoreceptors, adenylate and guanylate cyclases to the end of the second day after the acute stress action.
View Article and Find Full Text PDFStress itself as well as the subsequent myocardium necrosis developed after stress were mainly responsible for distinct decrease in concentration of somatotropin, somatomedin and for impairments in protein synthesis accompanied by decrease in proteins half-life in brain hemispheres and in non-ischemized heart left ventricle.
View Article and Find Full Text PDFEmotional stress caused distinct alterations in calcium metabolism and hypocalcemia development was observed. At the same time, negative balance of calcium, redistribution of calcium in tissues as well as alteration of the 3; 5'-AMP content in the tissues were noted.
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