[Reverse absorption of serotonin by synaptosomes and its level in the rat cerebral cortex in acute and chronic stress].

Acute stress was simulated in Wistar rats by means of uncontrolled electric shock within 6 hrs; chronic stress, after the first 6-hr course, was developed within 9 days using 1-h daily treatment. Within 18 hrs of the acute stress occurring concentration of serotonin was decreased 2-fold in tissues of brain cortex, while reverse absorption of the neurotransmitter in synaptosomes was increased 3-fold. Under conditions of chronic stress concentration of serotonin tend to increase, whereas reverse absorption by nerve endings was decreased, which appear to occur due to brain adaptation to chronic stress.

[Systems for regulating the level of Ca2+, cyclic nucleotides, and reverse absorption of neurotransmitters in isolated nerve endings of the rat brain during development of myocardial infarct].

The systems regulating the levels of Ca(2+)-Mg2+, Ca(2+)-ATPase and potential-dependent absorption of Ca2+ as well as content of cyclic nucleotides, beta-adrenoreceptors, activities of adenylate-, guanylate cyclases and phosphodiesterase were studied in the synaptosomes of rat brain cortex in evolving myocardial infarction. In addition, reverse absorption of noradrenaline, dopamine and serotonin was studied. In one of the animal groups myocardial infarction was simulated after stress.

[Adenylate cyclase system of synaptosomes from the rat cerebral cortex during acute stress].

Synaptosomes and synaptic membranes were studied in brain cortex of rats after 6 hrs emotional-painful stress. No alterations were observed in beta-adrenoreceptors, adenylate and guanylate cyclases to the end of the second day after the acute stress action.

[Changes in the levels of somatotropin and cyclic nucleotides and the state of protein metabolism in the brain and myocardium during stress as well as in myocardial necrosis following stress].

Stress itself as well as the subsequent myocardium necrosis developed after stress were mainly responsible for distinct decrease in concentration of somatotropin, somatomedin and for impairments in protein synthesis accompanied by decrease in proteins half-life in brain hemispheres and in non-ischemized heart left ventricle.

[Calcium metabolism and 3',5'-AMP levels in various organs in emotional-pain stress].

Emotional stress caused distinct alterations in calcium metabolism and hypocalcemia development was observed. At the same time, negative balance of calcium, redistribution of calcium in tissues as well as alteration of the 3; 5'-AMP content in the tissues were noted.