Rhizochalinin Exhibits Anticancer Activity and Synergizes with EGFR Inhibitors in Glioblastoma In Vitro Models.

Rhizochalinin (Rhiz) is a recently discovered cytotoxic sphingolipid synthesized from the marine natural compound rhizochalin. Previously, Rhiz demonstrated high in vitro and in vivo efficacy in various cancer models. Here, we report Rhiz to be highly active in human glioblastoma cell lines as well as in patient-derived glioma-stem like neurosphere models.

Spatial structure of the refracted field of a Gaussian light beam at total internal reflection.

The two-dimensional spatial structure of a stationary monochromatic refracted field is studied theoretically for the case of its exciting in a transparent homogeneous medium by incidence of a Gaussian light beam under total internal reflection. For that, the exact solution of refracted field in the form of a Fourier integral is used. It is shown that this spatial structure exhibits properties characteristic of the fields in strongly inhomogeneous and absorbing media: field attenuation as it propagates deep into the medium, noticeable diffraction beam divergence near the boundary itself, non-rectilinear nature of propagation in the medium, and non-exponential attenuation along its depth.

Efficiency of Gaussian light beam transformation into a waveguide mode of a plane dielectric layer under frustrated total internal reflection.

On the basis of the 2D analytic theory of the phenomenon of frustrated total internal reflection for a Gaussian light beam, produced by the authors in the previous paper [J. Opt. Soc.

Isotensor Dibaryon in the pp→ppπ^{+}π^{-} Reaction?

Exclusive measurements of the quasifree pp→ppπ^{+}π^{-} reaction have been carried out at WASA@COSY by means of pd collisions at T_{p}=1.2  GeV. Total and differential cross sections have been extracted covering the energy region T_{p}=1.

Spin Dependence of η Meson Production in Proton-Proton Collisions Close to Threshold.

Taking advantage of the high acceptance and axial symmetry of the WASA-at-COSY detector, and the high polarization degree of the proton beam of COSY, the reaction p[over →]p→ppη has been measured close to threshold to explore the analyzing power A_{y}. The angular distribution of A_{y} is determined with the precision improved by more than 1 order of magnitude with respect to previous results, allowing a first accurate comparison with theoretical predictions. The determined analyzing power is consistent with zero for an excess energy of Q=15  MeV, signaling s-wave production with no evidence for higher partial waves.