[The possibilities of gastroduodenal anastomosis reliability rising].

An experimentally-clinical assessment of reparative regeneration collagenation of gastroduodenal anastomosis was made. The anastomoses were formed by different ways: the inverted twin-row (classical) and everting one-row anastomosis. It was stated, that tissues repair on suture-line of the everting anastomosis took place faster and better (on a type of primary intention with wound epithelization on 3-5 days).

Synthesis and anti-viral activity of azolo-adamantanes against influenza A virus.

Chemotherapy and chemoprophylaxis of influenza is one of the most important directions of health protection activity. Due to the high rate of drug-resistant strains of influenza virus, there is a need for the search and further development of new potent antivirals against influenza with a broad spectrum of activity. In the present study, a set of di-, tri- and tetrazole derivatives of adamantane was efficiently prepared and their anti-influenza activities evaluated against rimantadine-resistant strain A/Puerto Rico/8/34.

Synthesis, molecular structure, and EPR analysis of the three-coordinate Ni(I) complex [Ni(PPh3)3][BF4].

The compound [Ni(PPh(3))(3)][BF(4)] x BF(3) x OEt(2) was isolated in crystalline form from the olefin oligomerization catalyst system Ni(PPh(3))(4)/BF(3) x OEt(2) and structurally characterized by X-ray diffraction. The influence of vibronic coupling on the EPR parameters of three-coordinate metal complexes with a 3d(9) electronic configuration was investigated within the framework of ligand field theory. Analytical expressions for g-tensor components and isotropic hyperfine coupling constants with ligand nuclei were obtained using first-order perturbation theory.

[New technologies for the treatment of complicated duodenal ulcers].

Billroth I gastric resection with end-to-end gastroduodenal anasthamosis was carried out to 73 patients with complicated duodenal ulcers using new technologies: duodenal mobilization only to the level of ulcer defect, the use of one-row (uninterrupted or nodal) everted suture with adaptation zone of submucous base of gastric stump and muscle coat of duodenal stump. Good early and long-term results were achieved.

Tuning of chemo- and regioselectivities in multicomponent condensations of 5-aminopyrazoles, dimedone, and aldehydes.

Regio- and chemoselective multicomponent protocols for the synthesis of 1,4,6,7,8,9-hexahydro-1H-pyrazolo[3,4-b]quinolin-5-ones, 5,6,7,9-tetrahydropyrazolo[5,1-b]quinazolin-8-ones, and 5a-hydroxy-4,5,5a,6,7,8-hexahydropyrazolo[4,3-c]quinolizin-9-ones starting from 5-amino-3-phenylpyrazole, cyclic 1,3-dicarbonyl compounds and aromatic aldehydes are described. Whereas the three-component coupling in ethanol under reflux conditions provides mixtures of pyrazoloquinolinones and pyrazoloquinazolinones, the condensation can be successfully tuned toward the formation pyrazoloquinolinones (Hantzsch-type dihydropyridines) by performing the reaction at 150 degrees C in the presence of triethylamine base applying sealed vessel microwave or conventional heating. On the other hand, using sonication at room temperature under neutral conditions favors the formation of the isomeric pyrazoloquinazolinones (Biginelli-type dihydropyrimidines).