Publications by authors named "V P Podzolkov"
Aim: To study the prognostic significance of hematologic indices: neutrophils/lymphocytes (N/L), platelets/lymphocytes (P/L) and lymphocytes/C-reactive protein (L/CRP) in relation to the complicated course of new coronavirus infection (COVID-19), as well as their correlation with COVID-19 course severity indices and endothelial dysfunction marker sVCAM-1.
Materials And Methods: 103 patients with new coronavirus infection (COVID-19) were included in the study. Based on the data of multispiral computed tomography (CT) of the chest organs, all patients were divided into 3 groups: CT group 1 - 30 patients, CT group 2 - 62 patients and CT group 3 - 11 patients.
Article Synopsis
- The study aimed to evaluate the frequency of polymorphisms in genes related to the renin-angiotensin system in COVID-19 patients and how these may correlate with the severity of the disease.* -
- It involved 100 hospitalized patients with confirmed COVID-19, analyzing specific genetic markers related to angiotensinogen, ACE1, and angiotensin II receptors to compare their frequencies with a general population.* -
- Results indicated a higher frequency of specific ACE1 alleles in these patients, with notable differences in the AGTR1 gene that may increase the risk of severe COVID-19, suggesting genetic factors could play a role in disease severity.*
Background: The high prevalence of traditional cardiovascular risk factors among the patients without cardiovascular disease (CVD) allows us to predict an increase in cardiovascular morbidity rate in the future. Arterial stiffness is one of the most important predictors and pathogenetic mechanisms of CVD development. The aim of our study was to evaluate the predictive differences of age-related and age-independent (universal) cardio-ankle vascular index (CAVI) reference values for detecting increased arterial stiffness in individuals without CVD.
View Article and Find Full Text PDFBackground: We conducted a study to determine the relationships between perirenal fat (PRF) thickness and urinary levels of monocyte chemoattractant protein-1 (MCP-1) and neutrophil gelatinase-associated lipocalin (NGAL) in patients with hypertension (HTN).
Methods: In 338 HTN patients (aged 63.5±12.
Article Synopsis
- The study investigates how different genetic variants (SNPs) in certain genes related to the renin-angiotensin system (RAS) affect the severity of COVID-19 in patients, particularly focusing on cardiovascular disease and hypertension as potential risk factors.
- Involving 100 hospitalized COVID-19 patients, the research classified them into severe and moderate cases based on specific clinical criteria, and analyzed genetic markers using advanced PCR methods.
- Findings indicate that specific SNPs, such as those in the ACE1 and AGTR1 genes, are linked to a higher severity of COVID-19, with significant genetic differences identified between the severe and moderate cases.