Publications by authors named "V P Pesic"
This study presents the first results from the analysis of water mites collected in Portugal as part of the Biodiversity Genomics Europe project. 307 COI DNA barcodes clustered into 75 BINs are provided, with 38 BINs being unique and deposited for the first time in the Barcode of Life Data Systems (BOLD). 65 species have been identified, of which 36 are new to the water mite fauna of Portugal.
View Article and Find Full Text PDFA pervasive exposure to stressors and the consumption of fructose-containing beverages usually go hand-in-hand in everyday life. In contrast to their metabolic outcomes, their impact on the brain and behavior is still understudied. We examined the behavioral response to a novelty (open field test), the expression of biochemical indicators of neuronal activity (Egr1 and FosB/ΔFosB), the synaptic potentiation (CaMKIIα and pCaMKII), the synaptic plasticity (synaptophysin, PSD95, gephyrin, and drebrin), and the GABAergic system (parvalbumin and GAD67), along with the glucocorticoid receptor (GR) and AMPK, in the medial prefrontal cortex of female Wistar rats subjected to liquid fructose supplementation (F), chronic unpredictable stress (S), or both (SF) over 9 weeks.
View Article and Find Full Text PDFTranslational research on cognitive impairment in chronic kidney disease.
Nephrol Dial Transplant
October 2024
Article Synopsis
- * Both traditional risk factors (like diabetes and high blood pressure) and kidney-specific factors (such as uremic toxins and chronic inflammation) can damage the blood-brain barrier and promote neuroinflammation, leading to cognitive impairments.
- * Recent animal model studies suggest new prevention and treatment strategies, focusing on the role of the blood-brain barrier, physical activity, and innovative therapies like SGLT2 inhibitors and GLP-1 receptor agonists in addressing cognitive decline in kidney disease.
Article Synopsis
- The link between chronic kidney disease (CKD) and cognitive function is gaining attention, particularly focusing on the effects of antibacterial agents (ABs) used in CKD patients who are more prone to infections.
- This review highlights how ABs can have direct neurotoxic effects on the central nervous system (CNS) and discusses how these medications can also alter gut microbiota, impacting cognitive symptoms through the brain-gut-kidney axis.
- The findings emphasize the need for careful monitoring of AB therapies in CKD patients to manage adverse drug reactions, particularly antibiotic-associated encephalopathy.
Risk of Death Among Nursing Home Residents: A Cross-National Perspective.
J Am Med Dir Assoc
September 2024
Article Synopsis
- The study aimed to analyze death rates among nursing home residents over a year and improve the CHESS scale for better risk categorization.
- Using data from over a million residents in Canada and the US, the researchers developed the DeathRisk-NH scale based on predictors identified through logistic regression.
- Findings showed a significant increase in death rates from 10.5% at 3 months to 30.7% at 12 months, highlighting the necessity of the DeathRisk-NH tool for effective patient care planning and monitoring.