Publications by authors named "V P Perevalov"
Article Synopsis
- Growing scientific interest in orthopoxvirus infections spurred by the 2022 mpox outbreak has led to a focus on developing new antiviral compounds.
- This research focuses on synthesizing new 2-arylimidazoles that show effectiveness against several orthopoxviruses, including the variola virus.
- Among the various imidazole derivatives, 1-hydroxyimidazoles stand out for their strong antiviral activity and unique structural features, with the most promising compound showing high selectivity against vaccinia and variola viruses.
Background: In 1980, smallpox became the first viral disease eradicated through vaccination. After the termination of the Smallpox Eradication Program, the global immunization of the population also ceased. Now, most people do not have any immunity against infections caused by orthopoxviruses.
View Article and Find Full Text PDFSmallpox was eradicated >40 years ago but it is not a reason to forget forever about orthopoxviruses pathogenic to humans. Though in 1980 the decision of WHO to cease vaccination against smallpox had seemed logical, it led to the decrease of cross immunity against other infections caused by orthopoxviruses. As a result, in 2022 the multi-country monkeypox outbreak becomes a topic of great concern.
View Article and Find Full Text PDFSelective pumping and probing of highly excited states of molecules are essential in various studies but are also challenging because of high density of states, weak transition moments, and lack of precise spectroscopy data. We develop a comb-locked cavity-assisted double-resonance spectroscopy (COCA-DR) method for precision measurements using low-power continuous-wave lasers. A high-finesse cavity locked with an optical frequency comb is used to enhance both the pumping power and the probing sensitivity.
View Article and Find Full Text PDFIntroduction: The study was designed to explore the mechanical properties of the self-adjusting file (SAF) and its application in the root canal using continuous irrigation.
Methods: The compressibility of the SAF file and the resulting peripheral force were measured using specially designed systems. The abrasivity of the file was tested on dentin blocks representing a flat root canal.