[Inactivation and sensitization of the tumor cells by the gene Bax transfection].

After the transfection of the gene Bax into the cultured tumor cells of human ovary adenocarcinoma SKOV3 and uterus carcinoma HeLa in vitro the high sensitivity of the cells SKOV3 to the protein Bax produced after the gene Bax transfection was found. The sensitivity of the cells HeLa to the gene Bax transfection was much smaller. The hyperexpression of gene Bax and hypersensitivity to doxorubicin were seen in HeLa cells received as a result of the gene Bax transfection and subsequent selection.

[Isolation of strains of Negishi virus in Khabarovsk Territory].

Two virus strains isolated from Aedes vexans nipponi and Aedes vexans vexans in 1976 and 1978, respectively, in Khabarovsk Territory were identified as Negishi virus. Among 176 human sera, 22.7% were found to contain complement-fixing antibodies to Negishi virus soluble antigen.

Differentiation in the complement fixation test of the viruses of tick-borne encephalitis complex by means of a type-specific soluble antigen.

Highly type-specific soluble antigens (SA) of viruses of the tick-borne encephalitis (TBE) complex were obtained by treatment of the sucrose-acetone antigens with 8 mol/l urea. Each SA reacted with the homologous serum only. The serum to SA of strain Sofyin and of Omsk haemorrhagic fever virus distinguished the TBE complex representatives; the difference between homologous serum titres was in the range of 4-5 two-fold dilution steps.

[Susceptibility of laboratory animals to the Chandipura and Isfahan viruses].

Pathogenicity and immunogenicity of Chandipura and Isfahan rhabdoviruses for laboratory animals were studied. Both viruses were found to be highly pathogenic for mice by the intracerebral route. Chandipura virus is highly pathogenic for mice of different ages by various routes of inoculation.