Publications by authors named "V P Novikov"
A low oxygen level in solid tumors is behind the modern concept of selective chemotherapy by hypoxia-activated prodrugs, such as heteroleptic complexes of transition metals (cobalt(III), iron(III) or platinum(IV)) with bi- or tetradentate ligands and an anticancer drug molecule as a co-ligand. A series of new cobalt(III) complexes [Co(LR)(esc)]ClO with esculetin (6,7-dihydroxycoumarin) and 2,2'-bipyridines (2,2'-bipy) functionalized by different substituents R were probed in the hypoxia-activated delivery of this model anticancer drug. Their combined study by cyclic voltammetry and NMR spectroscopy allowed identifying linear correlations of the electrochemical reduction potentials and the rate of the hypoxia-activated dissociation of [Co(LR)(esc)]ClO with the Hammett constants of the substituents in 2,2'-bipy ligands.
View Article and Find Full Text PDFPrevious research has demonstrated that a combined magnetic field (CMF) plays a critical role in modifying the properties of aqueous solutions, leading to an increase in the luminol-enhanced chemiluminescence of neutrophils. Using this model, the distant interaction between aqueous solutions was demonstrated, and the role of a CMF in the regulation of this phenomenon was established. In the current study, highly diluted (HD) phorbol myristate acetate (PMA) solution (the donor) was incubated with aqueous ethanol (the acceptor), both in a CMF-generating device and under geomagnetic field (GMF), for 0, 20, and 60 min.
View Article and Find Full Text PDFBladder cancer (BC) is a severe, and in some cases disabling disease for which no active detection strategy has been developed. It requires careful differential diagnosis, and is associated with a high risk for recurrence and progression. The choice of optimal treatment of non-muscle-invasive bladder Cancer (NMIBC) can reduce the rate of recurrence and improve oncologic outcomes.
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- The increasing demand for food packaging that ensures safety and quality is a significant challenge, and biodegradable polymers like poly(lactic acid) (PLA) present a solution.
- The study focuses on creating PLA-based materials with antibacterial properties by incorporating silver nanoparticles (AgNPs) stabilized by a copolymer and using advanced techniques to analyze their characteristics.
- Results suggest that these PLA-PEG biocomposites with AgNPs show promise for extending food storage while also being biodegradable.
Article Synopsis
- Bostrycoidin, a pigment from fungi, has pharmacological significance and indicates Fusarium infections in crops and soils.
- Researchers used density functional theory (DFT) to investigate the molecular structure and properties of bostrycoidin, analyzing its most stable geometry and energy levels of various conformers.
- The study successfully modeled the vibrational and electronic absorption spectra, with the calculated longest-wavelength transition aligning well with experimental results at approximately 498 nm.