[The prevention of stress-related postoperative and drug-induced erosive-ulcerative lesions of the upper digestive tract].

Based on the studies made in 84 patients with calculous cholecystitis and 12 patients with calcifying pancreatitis, an efficiency was shown of infusional administration of pyrencepine or ranitidine to prevent stress postoperative erosive-and-ulcerous lesions of gastroduodenal zone. Gastrocepine is shown to be superior to ranitidine and can be withdrawn without a maintenance dose, as well as becouse its cytoprotective effects with respect of the gastric and duodenal mucosa.

[The histoenzymological and ultrastructural changes in the gastric mucosa in peptic ulcer after treatment with pirenzepine and histamine H2-receptor blockaders].

A study made in 72 patients showed a positive influence in ulcer disease of gastrocepine and H2-blockers of receptors to histamine on histoenzymological and ultrastructural changes in the mucous membrane of the stomach and duodenum. Gastrocepine was found to be superior to H2-blockers of receptors to histamine due to its apparent cytoprotective effect and ability to improve microcirculation.

[The omeprazole treatment of patients with diseases of the upper digestive tract].

Effectiveness of the use of Omeprazolum (Oside) was studied in 24 patients with ulcer disease, 16 patients with chronic primary gastroduodenitis and 18 patients with acid reflux-esophagitis. The preparation Oside is a highly effective agent for the treatment of the aforementioned conditions and possesses a powerful antisecretory and antioxidant activity. Against the background of the use of the preparation the count of Helicobacter pylori gets decreased in the antral part of the stomach.