Publications by authors named "V P Mishin"
Article Synopsis
- - Since 2013, there have been 167 cases of people infected with special flu viruses from pigs in the U.S. called swine-origin influenza A.
- - Most of these viruses had a change in their genes that makes them resistant to certain medicines, but none were resistant to another type of medicine called neuraminidase inhibitors.
- - Scientists did tests to find out how well these viruses respond to treatments and discovered that one specific change in the virus made it much harder to treat with a medicine called baloxavir.
Influenza C virus susceptibility to antivirals with different mechanisms of action.
Antimicrob Agents Chemother
May 2024
Antiviral susceptibility of influenza viruses was assessed using a high-content imaging-based neutralization test. Cap-dependent endonuclease inhibitors, baloxavir and AV5116, were superior to AV5115 against type A viruses, and AV5116 was most effective against PA mutants tested. However, these three inhibitors displayed comparable activity (EC 8-22 nM) against type C viruses from six lineages.
View Article and Find Full Text PDFInfluenza virus neuraminidase (NA) can act as a receptor-binding protein, a role commonly attributed to hemagglutinin (HA). In influenza A(H3N2) viruses, three NA amino acid residues have previously been associated with NA-mediated hemagglutination: T148, D151, and more recently, H150. These residues are part of the 150-loop of the NA monomer.
View Article and Find Full Text PDFThis work was undertaken to evaluate the influence of friction-stir welding (FSW) under a high-heat input condition on microstructural evolution. Given the extreme combination of deformation conditions associated with such an FSW regime (including the highest strain, temperature, and strain rate), it was expected to result in an unusual structural response. For this investigation, a commercial 6013 aluminum alloy was used as a program material, and FSW was conducted at a relatively high spindle rate of 1100 rpm and an extremely low feed rate of 13 mm/min; moreover, a Ti-6Al-4V backing plate was employed to reduce heat loss during welding.
View Article and Find Full Text PDFArticle Synopsis
- Clade 2.3.4.4b HPAI A(H5N1) viruses have shown potential drug resistance, with about 0.8% of analyzed strains exhibiting markers for resistance to FDA-approved antivirals, indicating a possible public health threat.
- Testing revealed that most of these viruses remain susceptible to existing antivirals, particularly favoring investigational options like AV5080 over conventional treatments.
- Continued surveillance of these viruses is crucial for understanding their evolution and refining strategies for antiviral stockpiling to mitigate potential health risks.