[Problems of development, production and clinical use of highly effective blood substitutes].

An analysis of biological properties of blood substitutes has shown the expedience of wider clinical use instead of polyglucin of such substitutes as polyglucol, polifer, rondex, neorondex, polyoxidin, volecam; instead of rheopolyglucin--the rheopolyglucin with glucose, rheogluman and rheoglusol prepared for clinical tests; instead of haemodesin--haemodesin-H, neohaemodesin, gluconeodesin; instead of protein hydrolysates--polyamine and purified from peptides infusamine, hydromine, amicin; instead of 0.9% solution of sodium chloride--disol, quintasol, lactasol, mafusol. They have polyfunctional properties and considerably increase the effectiveness of the infusion--transfusion therapy.

[Experimental study of the antiproteinase activity of human alpha-2-macroglobulin concentrate].

20 series of alpha-2-macroglobulin (alpha 2-M) preparations with a specific activity of 15 +/- +/- 1 IU/mg were obtained by means of semi-industrial fractionation of human blood plasma Kohn 111 residue including polyethylene glycol and ethanol treatment. The preparations obtained inhibited proteolytic enzymes of fibrinolytic, kinin and blood coagulation systems as well as plant and bacterial proteinases. After intravenous administration of the alpha 2-M preparation into rats at a dose of 850-11,000 IU/kg the globulin concentration was correspondingly increased by 23-25% in blood.