Publications by authors named "V P Lupanov"

Current progress in numerical simulations and machine learning allows one to apply complex loading conditions for the identification of parameters in plasticity models. This possibility expands the spectrum of examined deformed states and makes the identified model more consistent with engineering practice. A combined experimental-numerical approach to identify the model parameters and study the dynamic plasticity of metals is developed and applied to the case of cold-rolled OFHC copper.

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The current instrumental studies (graded exercise echocardiography (ECG)), exercise tests in combination with myocardial imaging (echocardiography, myocardial perfusion scintigraphy) used to evaluate restenosis after percutaneous coronary interventions (PCI) in patients with coronary heart disease are considered. The sensitivity, specificity, and prognostic value of these studies versus coronarography in the diagnosis of restenosis after PCI are given. The capabilities of other diagnostic techniques (ultrasound study of brachial artery dysfunction, intravascular ultrasound study of coronary arteries, multispiral computed tomography, etc.

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Data of 5-year prospective follow-up were used for assessment of clinical course, prognosis and effectiveness of drug and nondrug treatment of 202 patients with ischemic heart disease, occlusive coronary artery atherosclerosis and preserved left ventricular function. It was found that 5-year cardiovascular mortality and rate of nonfatal myocardial infarction did not differ significantly between groups of patients subjected to drug treatment only, transluminal balloon angioplasty, and coronary artery bypass grafting.

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Clinical aspects of the use of organic nitrates in the treatment of patients with ischemic heart disease (IHD) are considered. Efficacy of organic nitrates in various forms of IHD as well as in patients with concomitant diseases is discussed. Special stress is made on clinical aspects of application of nitrates in treatment of IHD.

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Aim: Assessment of efficacy of treatment of coronary heart disease (CHD) patients suffering from stable effort angina of functional class II-III with the drug isosorbide-5-mononitrate Mono Mac 50 depo (MM 50 D).

Material And Methods: Clinical indices, exercise tolerance, endothelial function (the study of brachial artery in reactive hyperemia and sublingual intake of nitroglycerin) were studied in 30 patients with stable angina FC II-III before the treatment, 1 and 3 months after the treatment.

Results: MM 50D significantly widens diameter of the brachial artery (by 11.

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