[Demographic aspects of adaptive changes of human immune system in the North].

The dynamics of an immunotypological structure in migrants in Magadan was studied in relation to the duration of residence in the North. The changes were assessed by the integrated immune heterogeneity index, the atypic immune status index, frequencies of some immune phenotypes, the prevalence of clinical immunopathological signs and HLA Class 1 antigen distribution in the groups of the examinees. The dynamics of the immunotypological structure of migrants to the North was shown to have regular features depending upon the duration of "life in the North", some certain time-dependent, qualitative and quantitative characteristics.

[Assessment of interleukin-1 beta mRNA expression in the norm and pathology].

We investigated cytoplasmic RNA from the peripheral blood cells of pollinosis patients. Increased levels of IL-I mRNA were registered in neutrophils of patients suffering from pollinosis for a long time. Neutrophils from patients at the time of exacerbation of pollinosis responded to stimuli less than the cells from healthy donors.

[Causes of development and the role of immunodeficiency in trauma].

The authors provide evidence for a concept of pathogenetic heterogeneity of posttraumatic immunodeficiency, analyze the causes and mechanisms underlying the development of cellular, combined or humoral immunodeficiency having different (sano-, genetic or pathogenetic) influence) in trauma. Cellular immunodeficiency marked by suppression of cellular effector functions is considered as a sanogenetic factor stimulating reparation processes and protecting from infection via humoral immunity activation. Combined immunodeficiency with suppressed humoral and cellular effector functions forms a pathogenetic basis for infectious complications of trauma.

[Functional properties of B-lymphocytes of patients with a B-cell variant of chronic lymphocytic leukemia and chronic glomerulonephritis].

The common features of the pathogenesis of chronic lymphocytic leukemia (CLL) and chronic glomerulonephritis (CGN) have been shown as a result of a comprehensive study of the functional properties of B cells. Both CLL and CGN are accompanied by the appearance and accumulation of different types of activated B cells characterized by high spontaneous proliferation and/or Ig secretion; or sensitivity to T cell growth and differentiation factors; or capacity for Ig secretion; in mitomycin C treated B cell cultures (i.e.

[Evaluation of the activity of cytokine genes--a new diagnostic test in immunology].

The increased level of IL-1 mRNA was discovered in neutrophils of patients suffering from pollinosis for a long time and responding poorly to specific immunotherapy. Moreover, neutrophils from patients with exacerbation of pollinosis responded to stimuli less than cells from healthy donors. In remission, the activated neutrophils from pollinosis patients and healthy donors had the same levels of IL-1b mRNA.