Publications by authors named "V P Harjola"
Background: Cardiogenic shock (CS) is a heterogeneous clinical syndrome, making it challenging to predict patient trajectory and response to treatment. This study aims to identify biological/molecular CS subphenotypes, evaluate their association with outcome, and explore their impact on heterogeneity of treatment effect (ShockCO-OP, NCT06376318).
Methods: We used unsupervised clustering to integrate plasma biomarker data from two prospective cohorts of CS patients: CardShock (N = 205 [2010-2012, NCT01374867]) and the French and European Outcome reGistry in Intensive Care Units (FROG-ICU) (N = 228 [2011-2013, NCT01367093]) to determine the optimal number of classes.
Article Synopsis
- Cardiogenic shock (CS) is a life-threatening condition linked to severe heart issues, particularly in patients with ST-segment elevation myocardial infarction (STEMI), where the role of epigenetic factors, like miRNAs, is not well understood.
- In a study involving 49 STEMI patients, researchers found that miR-619-5p levels were significantly higher in those experiencing CS compared to those without, indicating its potential as a biomarker for assessing risk and mortality outcomes.
- The study concluded that miR-619-5p not only correlates with inflammatory responses but also serves as a critical indicator for predicting patient mortality within a 30-day follow-up in CS patients.
Acute right ventricular failure secondary to acutely increased right ventricular afterload (acute cor pulmonale) is a life-threatening condition that may arise in different clinical settings. Patients at risk of developing or with manifest acute cor pulmonale usually present with an acute pulmonary disease (e.g.
View Article and Find Full Text PDFImportance: Electric scooter (e-scooter) crashes have become a serious health issue worldwide. The need for effective e-scooter regulations has been established in numerous instances.
Objective: To investigate the association of restrictions on top speed and nighttime usage on the incidence of e-scooter-related injuries.
Article Synopsis
- Acute heart failure (AHF) is a complex condition influenced by both sudden triggers and existing heart issues, often linked to valvular heart disease (VHD).
- Patients with AHF may show varying symptoms, ranging from mild heart failure to severe cases like cardiogenic shock, making it tough to assess their condition accurately.
- Current treatment guidelines for AHF patients with severe VHD are unclear due to limited evidence from clinical trials, prompting a need for more research on this specific group.