[The effect of regulator peptides on pancreatic endocrine function in experimental acute pancreatitis].

The comparative analysis of the influence on the glucose metabolism of rats in acute pancreatitis of synthetic analogues was made: somatostatin, calcitonin, leu-enkefalin-dalargin. It was shown that dalargin has the maximum normalizing effect as a result of its antistress qualities. Physiological reaction of beta-cells is preserved in infusion of somatostatin.

[A comparative study of the effectiveness of regulatory peptides in acute experimental pancreatitis].

The effect of regulatory peptides on the functional activity of pancreatic cells and phagocytic cells of reticuloendothelial system were determined in intact dogs against the background of acute experimental pancreatitis. Assessment of the efficacy of regulatory peptides was made with the aid of scintigraphic studies in gamma chamber using for this purpose colloid 198Au and 75Se-methionine. It was established that introduction of regulatory peptides to dogs leads to inhibition of capture of labeled methionine by pancreatocytes, practically not influencing the elimination of colloid gold from circulation.

[Effects of several regulatory peptides on the functional activity of the pancreas in acute experimental pancreatitis].

The influence of regulatory peptides (somatostatin, calcitonin, and dalargin) on xanthine oxidase activity and lipid peroxidation level in pancreatic tissues as well as on the release of pancreatic enzymes (alpha-amylase, trypsin, lipase, and transamidinase) into blood was studied in 205 rats with experimental acute pancreatitis. Somatostatin and dalargin were shown to have obvious antioxidant effect seen by reduced xanthine oxidase activity and MDA level. All studied peptides stimulate reduced release of pancreatic enzymes.

[Role of xanthine oxidase in the genesis of acute pancreatitis].

Experiments were conducted on 268 male albino rats with modeled acute pancreatitis to study the xanthine oxidase (XO) activity in the pancreatic tissue during intraperitoneal administration of stimulators of pancreatic exocrine function (pilocarpine) and inhibitors of enzyme activity (allopurinol). Pilocarpine (0.1 mg/kg) increased XO activity by 90-100% one-three hours after injection, which was due to increased synthesis of the enzyme.

[Changes in the external respiration function and hemodynamics after surgery of the pancreas].

Pancreatic surgical operations, being very traumatic, cause considerable and lasting disorders on the part of external respiration, gas exchange, and central and regional hemodynamics. Patients with pancreatic tumors show systolic myocardial strain, which may be related to increased sympatho-adrenal influences. In the early days after pancreatoduodenal resection for pancreatic tumors, patients develop hyperdynamic circulation.