Publications by authors named "V P Coelho"
Safety of two-dose schedule of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan) and heterologous additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised and immunocompetent individuals.
Rev Inst Med Trop Sao Paulo
January 2025
Immunocompromised individuals were considered high-risk for severe disease due to SARS COV-2 infection. This study aimed to describe the safety of two doses of COVID-19 adsorbed inactivated vaccine (CoronaVac; Sinovac/Butantan), followed by additional doses of mRNA BNT162b2 (Pfizer/BioNTech) in immunocompromised (IC) adults, compared to immunocompetent/healthy (H) individuals. This phase 4, multicenter, open label study included solid organ transplant and hematopoietic stem cell transplant recipients, cancer patients and people with inborn errors of immunity with defects in antibody production, rheumatic, end-stage chronic kidney or liver disease, who were enrolled in the IC group.
View Article and Find Full Text PDFIntroduction: Laterality judgement evaluates the capacity to differentiate between the left and right sides of bodily parts. Cortical body representations are impaired in various musculoskeletal conditions, yet this remains unexplored in individuals with patellofemoral pain (PFP).
Objective: This study compared laterality judgement performance between individuals with PFP and asymptomatic controls.
Chlorpyrifos intermittent exposure enhances cardiovascular but not behavioural responses to contextual fear conditioning in adult rats: Possible involvement of brain oxidative-nitrosative stress.
Behav Brain Res
February 2025
Article Synopsis
- Exposure to organophosphorus compounds, like chlorpyrifos (CPF), can lead to various health issues affecting the brain and heart, primarily due to the inhibition of the enzyme acetylcholinesterase (AChE).
- In a study on rats, intermittent CPF treatment was found to increase anxiety and impair motor functions, but it did not significantly affect depression symptoms or fear responses after a washout period.
- Measurement of AChE activity showed significant reductions in key brain areas, indicating a link between CPF exposure and neurotoxicity, particularly at higher doses.
Objective: To evaluate whether the presence of dental caries in the primary anterior teeth of 1- and 2-year-old babies can predict the occurrence of severe dental caries in the primary posterior teeth of these children after a 3-year follow-up.
Methodology: This cohort study was carried out with 99 children and their guardians who were assessed at the beginning of the study and reassessed after 3 years. Severe caries in posterior tooth at the 3-year follow-up is the dependent variable.