Publications by authors named "V P CHERNYSHENKO"
Soluble fibrin is composed mainly of desA fibrin and fibrinogen oligomers consisting of fewer than 16 monomers partially cross-linked by factor XIIIa. Soluble fibrin cannot stimulate Glu-plasminogen activation by tissue plasminogen activator (t-PA); therefore, it may not be a direct predecessor of D-dimer. However, within the microcirculatory system, soluble fibrin oligomers may form microclots.
View Article and Find Full Text PDFPreviously, the direct interactions of Bβ26-42 fibrin residues with prothrombin were demonstrated. It was also shown that forming prothrombin complexes with E- or DDE-fragments causes non-enzymatic prothrombin activation. The direct measuring of the prothrombin level in the blood plasma of patients with acute myocardial infarction (AMI) allowed us to find a situation where such an activation can occur in vivo.
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- Fibrinogen is a complex plasma protein with αC-domains crucial for processes like blood clot formation, platelet aggregation, and cell interactions.
- Specific truncated forms of fibrinogen were created to study the roles of its N-terminal and C-terminal sub-domains.
- Results showed that both sub-domains contribute to fibrin polymerization and platelet aggregation, with the N-terminal being more influential in aggregation and the C-terminal significantly impacting cell viability and cancer cell migration.
Background: Knowing the variability of blood coagulation responses to liver damage of different origins can provide a key to curing liver tissues or to mitigating treatment side effects. The aim of the present work was to compare the changes in the main components of hemostasis under experimental drug-induced hepatosis and hepatitis in rats.
Methods: We modeled diclofenac-induced hepatitis and tetracycline-induced hepatosis.
N-stearoylethanolamine (NSE), a lipid mediator that belongs to the N-acylethanolamine (NAE) family, has anti-inflammatory, antioxidant, and membranoprotective actions. In contrast to other NAEs, NSE does not interact with cannabinoid receptors. The exact mechanism of its action remains unclear.
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