Large-scale prediction of biological activities with Active-IT system.

Traditional testing methods in pharmaceutical development can be time-consuming and costly, but in silico evaluation tools can offer a solution. Our in-house Active-IT system, a Ligand-Based Virtual Screening (LBVS) tool, was developed to predict the biological and pharmacological activities of small organic molecules. It includes four independent modules for generating molecular descriptors (3D-Pharma), machine learning modeling (ExCVBA), a database of bioactivity models, and a prediction module.

Predisposing factors for symptoms of anxiety, depression, and insomnia in university students.

Objectives: to characterize the sociodemographic and psychological aspects of university students who sought psychiatric care at a Student Support Center of a Federal University and to analyze associations between mental health issues and predisposing factors.

Methods: a retrospective analysis of 103 medical records was conducted. The statistical analysis consisted of two steps: a descriptive analysis and a predictive analysis using the Logistic Regression Model.

Effects of Paradoxical Sleep Deprivation on MCH and Hypocretin Systems.

Melanin-concentrating hormone (MCH) and hypocretins (Hcrt) 1 and 2 are neuropeptides synthesized in the lateral hypothalamic area by neurons that are critical in the regulation of sleep and wakefulness. Their receptors are located in the same cerebral regions, including the frontal cortex and hippocampus. The present study aimed to assess whether 96 hours of paradoxical sleep deprivation alters the functioning of the MCH and hypocretin systems.

Treatment Approaches to Myasthenia Gravis and Obstructive Sleep Apnea: Case Report.

Myasthenia gravis (MG) is a chronic autoimmune disease characterized by progressive weakness and skeletal muscle fatigue due to the destruction of acetylcholine receptors, causing an abnormality in the synaptic junction between innervation and muscle fibers. The treatment of patients with MG and obstructive sleep apnea (OSA) is positive pressure in the airway; however, the lack of adherence to the protocol can lead to increased morbidity. A known alternative treatment for OSA is the mandibular advancement device (MAD).

Unexpected Airway Obstruction in a Patient With Undiagnosed Granulomatosis With Polyangiitis.

Granulomatosis with polyangiitis (GPA) is a rare systemic vasculitis that can involve the respiratory tract and lead to severe airway complications. We present a 61-year-old female with an undiagnosed GPA who experienced severe airway obstruction and rapid deterioration during a flexible bronchoscopy. Severe glottic edema and reduced vocal cord mobility resulted in a challenging airway and rapid desaturation, and ultimately led to cardiac arrest.