[Gliomatosis cerebri as cause of neuropsychiatric symptoms].

Gliomatosis cerebri (GC) is a rare cancer of the central nervous system, having already penetrated into various areas of the central nervous system upon becoming manifest. In tissue specimens the histopathologic picture of the tumor appears similar to that seen in diffuse gliomas at different stages of disease. Typical MRI findings in GC include diffuse increases in signal intensity in the brain, and indistinct gray-white matter demarcation in T2-weighted images.

[Determination of pentoxifylline and its major metabolites in human plasma using HPLC].

The present paper describes a rapid, reliable and simple method of pentoxiphyllin in plasma. The worked-out one-step extraction with dichloromethane yields 63% recovery of pentoxiphyllin, 58% recovery of the metabolite and 54% recovery of the internal standard. The employed column with a reverse load of Spherisorb ODS, mobile phase 65% of 0.

[Determination of nifedipine and its metabolites in plasma using gas chromatography].

A method was worked out to determine nifedipine and its metabolite in plasma with the use of the packed chromatographic column 3% OV-101 and the detector of electron capture. The adjustment od plasma is simple. It consists in denaturation of plasma proteins and subsequent simple extraction with benzene.

Optimization of fluorescence detection for the determination of labetalol in plasma by high-performance liquid chromatography.

A sensitive reversed-phase high-performance liquid chromatographic method for the determination of labetalol has been developed. A mobile phase consisting of citrate buffer (pH 6.5), acetonitrile and 2-propanol and an RP-8 column were used.