Prevention of lipopolysaccharide-induced intussusception in mice by the COX2 inhibitor rofecoxib.

Intussusception (IS), an invagination of a portion of the intestine into itself, has recently attracted considerable interest after the withdrawal of a rotavirus vaccine because of reports on increased risk of IS shortly after vaccination. The present study was designed to shed further light on the mechanism of IS formation and its prevention. Intussusception was induced in adult mice by intraperitoneal injection of lipopolysaccharide (LPS; 8 mg/kg) from salmonella typhimurium.

Study of zinc content in blood serum of the patients with malignant tumors of the digestive systems.

Zinc (Zn)--the important atomavit (essential chemical element), which participates in 120 reactions proceeding in a living organism. There were been found the abnormal Zn-levels in blood in the cases of the various pathologies, including malignant tumors (MT) of the digestive systems. It has been determined the Zn-levels in the blood serum of 48 patients with MT of the digestive systems (nosologies: 24--MT of stomachs, 10--esophagus, 14--colorectum) and 12 practically healthy persons.

[Study of serum levels of magnesium in the patients with malignant tumors].

The main goal of the study was the evaluation of serum levels of magnesium in the practically healthy persons (control group), the patients with different malignant tumors (abdominal, pulmonary, uterus, breast, esophagus, rectum), as well as benign tumors of the breast/the uterus and the inflammatory pulmonary diseases. Content of Mg in blood serum was determined using the method of atomic-absorption spectrophotometry. It has been found that, in comparison with norm (23.

Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes.

The immune system depends on chemokines to recruit lymphocytes to tissues in inflammatory diseases. This study identifies PDE8 as a new target for inhibition of chemotaxis of activated lymphocytes. Chemotactic responses of unstimulated and concanavalin A-stimulated mouse splenocytes and their modulation by agents that stimulate the cAMP signaling pathway were compared.

Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL.

Here, we provide evidence for a detrimental role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in neural death in T cell-induced experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). Clinical severity and neuronal apoptosis in brainstem motor areas were substantially reduced upon brain-specific blockade of TRAIL after induction of EAE through adoptive transfer of encephalitogenic T cells. Furthermore, TRAIL-deficient myelin-specific lymphocytes showed reduced encephalitogenicity when transferred to wild-type mice.