Publications by authors named "V Oddone"
Background: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by the development of autoantibodies and the impairment of the coagulation system. Knowledge about this syndrome is increasing over time, but kidney involvement, especially APS nephropathy, still represents a challenge for physicians.
Summary: A "two hit" model has been hypothesized to explain APS pathophysiology, and the role played by some factors, such as the complement system, is becoming more and more clear.
Background: Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a cluster of potentially life-threatening disorders, often involving the kidney with a necrotizing crescentic glomerulonephritis with scanty deposition of immunoglobulins and complement. Historically the role of complement has been considered ancillary. Recently, an anti-myeloperoxidase (MPO) AAV model in complement-deficient mice has shown an involvement for the complement cascade in the development of the renal injuries.
View Article and Find Full Text PDFIntroduction: To date, almost 7 billion doses of the different types of vaccine against SARS-CoV-2 have been administered worldwide. Although the severity of new cases of SARS-CoV-2 has progressively decreased, and the pressure on national health systems has declined, the development of de novo glomerular injuries has been suggested.
Methods: This study aimed to examine the patients who were hospitalized in our Unit between April and November 2021 and underwent renal biopsy for new-onset urinary abnormalities (UA) and/or renal impairment within 3 months of SARS-CoV-2 vaccination.
Objectives: No agent has yet been proven to be effective for the treatment of patients with severe COVID-19.
Methods: We conducted a pilot prospective open, single-arm multicentre study on off-label use of tocilizumab (TCZ) involving 63 hospitalised adult patients (56 males, age 62.6±12.
Article Synopsis
- The paper investigates how thermal conductivity relates to the strength of metal matrix composites, using Al2024 and Mg-0.9Ca alloys reinforced with graphite flakes as case studies.
- It combines both theoretical and experimental methods to analyze stress concentration in these composites, particularly focusing on the spacing between graphite flakes and its connection to thermal conductivity.
- The findings show a strong alignment between theoretical predictions and experimental results, provided that the inhomogeneities in the material are uniformly distributed and of identical shape.