Publications by authors named "V O Speights"
Objectives: We evaluated how the changes in Gleason grading affected the long-term outcomes of a large prostatectomy cohort.
Methods: We obtained long-term follow-up (16.7 years) in 581 patients having undergone radical retropubic prostatectomy between 1985 and 1995.
Histopathologic examination of bone specimens coupled with bone culture is considered the gold standard for the diagnosis of osteomyelitis (OM). Despite this, studies have demonstrated interpathologist agreement in the diagnosis of OM as low as 30%, largely stemming from a lack of specific definitions and diagnostic criteria. Review of the literature has provided insight into the lifecycle of OM, illustrating the histologic progression of OM phases from acute to chronic, and provides support for defining subcategories of OM.
View Article and Find Full Text PDFBackground: New biologic therapies directly injected into the prostate are in clinical trials for prostatic diseases. There is a need to understand distribution of injected therapies as a function of prostatic anatomy, physiology, and device design.
Methods: A needle with a porous length of customizable-length was tested and its performance compared with a standard needle.
Background: Historically, ploidy and S phase percentage appeared to be promising predictors for prostate cancer recurrence. Lack of uniformity and consistency hampered their development. We evaluated ploidy and S phase for prostate cancer death in a cohort of patients with long-term follow-up.
View Article and Find Full Text PDFArticle Synopsis
- - The study aims to differentiate between primary esophageal adenocarcinomas and those that have metastasized from the lungs using specific immunohistochemical markers.
- - Researchers analyzed 24 cases each of pulmonary and esophageal adenocarcinomas with various markers, noting that TTF-1 and napsin A were similarly present in both tumor types.
- - The study concludes that a panel of IMP3, CDX2, and N-cadherin is more effective for distinguishing between the origins of these tumors compared to TTF-1 or napsin A.