[Changes of intracellular calcium-regulating mechanisms of primary and secondary sensory neurones in periferal inflammation].

Here we summarize the results of experimental investigation of changes in intracellular calcium homeostasis in mice and rat primary (dorsal root ganglia, DRG) and secondary (dorsal horn, DH) sensory neurons under carrageenan-induced periferal inflammation. A decrease in a calcium accumulation in both inositoltriphosphate- and caffeine-sensitive endoplasmic reticulum calcium stores has been detected in primary sensory neurons under condition of peripheral inflammation. We have also shown a decrease in the caffeine-induced calcium release in dorsal horn neurons of inflamed rat as compared to control ones.

[Changes in intracellular mechanisms in sensory neurons in experimental diabetes mellitus].

Here we summarises the results of experimental investigation of changes in intracellular calcium homeostasis in sensory neurones of rats with streptozotocin-induced diabetes mellitus. Decrease in the calcium-accumulating function of both inositol-trisphosphate- as well as caffeine-sensitive endoplasmic reticulum has been detected both in primary sensory neurones of dorsal root ganglia and in secondary neurones of the spinal cord dorsal horn. Predominant depression in the functioning of metabotropic receptors of ligand-gated channels compared with those of ionotropic ones has been demonstrated.