Publications by authors named "V O Ona"
: Radical cystectomy (RC) represents one of the most complex and morbid surgical procedures in the field of Urology. Extraperitoneal open RC has emerged as an alternative to the traditional transperitoneal approach for the treatment of muscle-invasive bladder cancer. Frailty is one of the most important risk factors for perioperative morbidity and mortality, and this category of patients can benefit the most from the extraperitoneal approach.
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- - Zuranolone is a new oral treatment for postpartum depression, explored in a trial assessing its cognitive effects, safety, and pharmacokinetics when taken alone or with alprazolam or ethanol.
- - In the study, participants showed small-to-moderate cognitive decline when taking zuranolone, with greater declines observed when it was combined with alprazolam or ethanol.
- - Despite the cognitive effects, the study found no significant pharmacokinetic interactions between zuranolone and the other substances, though prescribers should note the heightened risk of CNS depression when used together.
Effects of zuranolone on next-day simulated driving in healthy adults.
Psychopharmacology (Berl)
September 2024
Article Synopsis
- Zuranolone is a medication that affects GABA receptors in the brain and could influence activities that require focused thinking, like driving.
- In a study involving 67 healthy adults, participants were given either zuranolone or a placebo, and their driving performance was measured using a simulator, focusing on how much the car swerved (standard deviation of lateral position, SDLP).
- Results showed that zuranolone significantly impaired driving performance and cognitive abilities shortly after dosing, with effects persisting even after a week of treatment, highlighting the need for caution when prescribing the drug.
Extensive literature probes labor market discrimination through correspondence studies in which researchers send pairs of resumes to employers, which are closely matched except for social signals such as gender or ethnicity. Upon perceiving these signals, individuals quickly activate associated stereotypes. The Stereotype Content Model (SCM; Fiske 2002) categorizes these stereotypes into two dimensions: warmth and competence.
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- The study aimed to evaluate the safety, pharmacokinetics (how the drug moves through the body), and pharmacodynamics (the effects of the drug) of M6495, a new medication, in healthy volunteers and osteoarthritis patients.
- Two randomized, placebo-controlled studies were conducted: one with healthy men and another with osteoarthritis patients, assessing various doses and administration methods of M6495 over a period of 106 days.
- Results showed that M6495 was well tolerated with minimal adverse effects and significantly reduced biomarkers associated with osteoarthritis, indicating its potential as a disease-modifying treatment.