Application of serex-analysis for identification of human colon cancer antigens.

Background: Colorectal, lung and breast tumors are the most devastating and frequent malignances in clinical oncology. SEREX-analysis of colon cancer leads to identification of more than hundred antigens which are potential tumor markers. With idea that immunoscreening with pool of allogeneic sera is more productive for antigen isolation, SEREX-analysis was applied to four cases of stages II-IV primary colon tumor and 22 new antigens were isolated.

[Possibilities of application of palliative cryodestruction for the treatment of patients with nonresectable local recurrence of rectal cancer].

The cancer recti local recurrence is nonresectable in 50-70% of observations, it is treated using irradiation or chemo-irradiation therapy, which improve the patients quality of life and guarantee the 12-13 mo survival mediana. In subsequent progressing disease cryosurgical method of treatment is applied. The results of it application in 22 patients are presented.