Publications by authors named "V Nussenblatt"
Article Synopsis
- Adoptive cellular therapies (ACT), including CAR T cells, TILs, TCRs, and CAR-NK cells, are innovative treatments for severe cancers, recently approved by the FDA for various malignancies.
- While these therapies show potential, they can lead to serious complications, especially increased risks for severe infections due to weakened immune systems from both cancer and treatment.
- This review focuses on the infectious complications associated with ACTs, particularly examining COVID-19 risks for CAR-T patients to shed light on similar risks for other ACT recipients.
Article Synopsis
- Cutaneous protothecosis is an uncommon infection that affects the skin and can spread systemically, requiring long-term treatment with medications that may have harmful side effects.
- The case study focuses on a patient whose skin infection did not respond to standard triazole treatment.
- The patient showed significant improvement after being treated with a new oral formulation of amphotericin B, which was effective without causing any toxicity.
Considerations for the Use of Phage Therapy in Clinical Practice.
Antimicrob Agents Chemother
March 2022
Increasing antimicrobial resistance and medical device-related infections have led to a renewed interest in phage therapy as an alternative or adjunct to conventional antimicrobials. Expanded access and compassionate use cases have risen exponentially but have varied widely in approach, methodology, and clinical situations in which phage therapy might be considered. Large gaps in knowledge contribute to heterogeneity in approach and lack of consensus in many important clinical areas.
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